SKYTROFA is now FDA approved for adults with growth hormone deficiency Learn More
SKYTROFA Auto-Injector photo SKYTROFA Auto-Injector photo

SKYTROFA Auto-Injector—award-winning innovation in your hands

Unplug. Inject. Go.

The innovative SKYTROFA Auto-Injector provides clear direction at every step of the process with precise mixing and automated injection.

Needle guard
Starts injection when pressed against skin
Inspection window
Allows for inspection of mixed medicine
Progress bar
Shows progress of mixing and injection
Check mark
Indicates injection is successfully completed
Eye
Indicates mixed medicine is ready for inspection in window
Mixing
Indicates medicine mixing is in progress
Button
To turn on Auto-Injector or reject mixed medicine
Needle
Cartridge
Contains medicine and water for injection
Battery icon
SKYTROFA-Auto-Injector Diagram Photo

Innovative features

no refrigeration icon

No refrigeration, no preservatives

SKYTROFA cartridges do not need to be refrigerated for up to 6 months.* SKYTROFA is preservative free. Each single-dose cartridge contains only lonapegsomatropin-tcgd, diluent, and sterile water.

SKYTROFA-no-dialing-icon

No need to dial the dose

SKYTROFA comes in ready-to-use, color-coded cartridges for the prescribed dose. During administration, the Auto-Injector delivers the entire dose without wasting medicine

  • All cartridges work in the SKYTROFA Auto-Injector
  • SKYTROFA has a range of dosage strengths. Your doctor can easily adjust your child’s prescribed dose as they grow
SKYTROFA small needle icon

Small needle size selected with your child’s comfort in mind

Uses a thin, 31-gauge needle provided to patients with every SKYTROFA cartridge delivery

  • The SKYTROFA Auto-Injector has a needle guard that conceals the needle during injections
rechargeable auto-injector icon

Unplug, inject, and go

The Auto-Injector is reusable and rechargeable. It reduces the waste of disposable injector pens and batteries. A full charge lasts for 4 weeks, with 1 injection per week

  • The Auto-Injector is designed to last up to 4 years or 210 injections, whichever comes first
*Store SKYTROFA in the original package to protect from light. Do not freeze. SKYTROFA can be stored at room temperature (not to exceed 86°F [30°C]) for up to 6 months. Alternatively, SKYTROFA can be stored under refrigeration at 36°F to 46°F (2°C to 8°C) until the expiration date. If refrigerated, keep at room temperature for 15 minutes before use. Do not use SKYTROFA beyond the expiration date or 6 months after the date it was first removed from refrigeration (whichever is earlier).

Watch: How to use the SKYTROFA Auto-Injector

See the simple steps to growth with the SKYTROFA Auto-Injector. For detailed instructions, download and read the Instructions for Use.

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*Patients who require 2 cartridges per week will need to repeat the steps shown. It is important to be trained by an HCP on how to use your Auto-Injector prior to first use.

See what real parents and caregivers have to say about the SKYTROFA Auto-Injector.

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Leverage tools that you already have available to help remind you about your weekly injections

calendar reminder icon

Create a weekly calendar reminder

medication-alarm-icon

Set an alarm on your smartphone⁠—⁠you can even choose a unique ringtone

voice commands icon

Use voice commands with your smart home devices

medication reminder icon

Explore medication reminder apps

Triple-award-winning Auto-Injector device recognized for its innovative, patient-centric product design

Usability

Selected for its patient-centric design in the Health Product category

Innovation

Recognized for technical innovation in advancing the field of bio/pharmaceutical manufacturing

Industrial Design

Awarded for outstanding, high‑quality product design

asap reminders photo

You can get injection reminders from the A·S·A·P Messaging Service. Sign up for your weekly text reminder now.

Sign Up
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Speak with your doctor about choosing SKYTROFA

Let your doctor know you are interested in once-weekly SKYTROFA today.

Get Started

IMPORTANT SAFETY INFORMATION & USES

SKYTROFA is a prescription medicine used for:

  • the replacement of growth hormone in children 1 year old or older who weigh at least 26 pounds (11.5 kilograms) with growth hormone deficiency (GHD)
  • the replacement of growth hormone in adults with growth hormone deficiency (GHD)

Do not take SKYTROFA if:

  • you have a critical illness caused by certain types of heart or stomach surgery, trauma or breathing problems
  • you are allergic to somatropin or any of the ingredients in SKYTROFA

IMPORTANT SAFETY INFORMATION & USES

SKYTROFA is a prescription medicine used for:

  • the replacement of growth hormone in children 1 year old or older who weigh at least 26 pounds (11.5 kilograms) with growth hormone deficiency (GHD)
  • the replacement of growth hormone in adults with growth hormone deficiency (GHD)

Do not take SKYTROFA if:

  • you have a critical illness caused by certain types of heart or stomach surgery, trauma or breathing problems
  • you are allergic to somatropin or any of the ingredients in SKYTROFA
  • you are a child with closed bone growth plates
  • you have cancer or other tumors
  • you have certain types of eye problems caused by diabetes
  • you are a child with Prader-Willi syndrome who is severely obese or has breathing problems including sleep apnea (briefly stopping breathing during sleep)

Tell your healthcare provider if you are pregnant or plan to become pregnant, about all of your medical conditions, and about all the medicines you take. SKYTROFA may affect how other medicines work, and other medicines may affect how SKYTROFA works.

What are the possible side effects of SKYTROFA?

SKYTROFA may cause serious side effects, including:

  • serious allergic reactions. Get medical help right away if you have swelling of the face, mouth, tongue, or throat or trouble breathing
  • high risk of death in people who have critical illnesses caused by heart or stomach surgery, trauma, or serious breathing problems
  • increased risk of growth of an existing tumor or cancer, or increased risk of a previous tumor or cancer returning in people who were treated with radiation to the brain or head as children and who developed low growth hormone problems. Your healthcare provider will need to monitor for the growth or return of a tumor or cancer. Contact your healthcare provider if you start to have sudden changes in behavior, headaches, vision problems, or changes in moles, birthmarks, or skin color
  • new or worsening high blood sugar or diabetes. Your blood sugar may need to be monitored during treatment with SKYTROFA
  • increase in pressure in the skull. Contact your healthcare provider if headaches, eye problems, nausea, or vomiting occur
  • too much fluid in the body (fluid retention). Contact your healthcare provider if you notice swelling in the hands and feet, pain in the joints or muscles, or nerve problems that cause pain, burning or tingling in the hands, arms, legs, and feet
  • decrease in a hormone called cortisol. Your healthcare provider will do blood tests to check your cortisol levels
  • decrease in thyroid hormone levels. Decreased thyroid hormone levels may affect how well SKYTROFA works. Your healthcare provider will do blood tests to check your thyroid hormone levels
  • hip and knee pain or a limp in children (slipped capital femoral epiphysis). This may lead to a serious condition where bone tissue dies due to a lack of blood supply (osteonecrosis). Get medical help right away for children who develop a limp or have hip or knee pain
  • worsening of curvature of the spine in children (scoliosis)
  • severe and constant abdominal pain. This could be a sign of pancreatitis. Tell your healthcare provider about any new abdominal pain
  • loss of fat and tissue weakness in the area of skin you or your child inject. Talk to your healthcare provider about rotating the areas where SKYTROFA is injected
  • high risk of sudden death in children with Prader-Willi syndrome who are severely obese or have breathing problems, including sleep apnea
  • increase in phosphate, alkaline phosphatase, and parathyroid hormone levels in your blood. Your healthcare provider will do blood tests to check this

The most common side effects of SKYTROFA in children include: viral infection, fever, cough, nausea and vomiting, bleeding, diarrhea, stomach area pain, joint pain and arthritis

The most common side effects of SKYTROFA in adults include: swelling due to fluid build-up and low thyroid hormone

These are not all of the possible side effects of SKYTROFA. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ascendis Pharma at 1-844-442-7236.

Please click here for SKYTROFA full Prescribing Information.

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